Monday, October 31, 2011

Va GOP hits graphic of zombie Obama shot in head (AP)

RICHMOND, Va. ? A Halloween-themed graphic featuring a zombie President Barack Obama with a bullet hole in his forehead provoked widespread outrage and the attention of the Secret Service Monday after a local Republican committee in Virginia used it to scare up interest in Halloween parade political activities.

The montage, a banner on a mass email to Loudoun Republicans, mingles seasonal images including a jack-o-lantern, a disfigured U.S. Rep. Nancy Pelosi and a throng of flesh-hungry zombie Obama supporters.

The posterized image of a rotting, undead Obama with a bleeding, large-caliber hole an inch above his right eye prompted Democrats to cry foul and Virginia's Republican governor to denounce it as "shameful and offensive."

"This is a disgusting and violent portrayal of the president of the United States," said Democratic Party of Virginia spokesman Brian Coy.

Gov. Bob McDonnell, through spokesman J. Tucker Martin, called on the Loudoun GOP to "apologize for their actions, and to immediately ensure that such imagery is never used again."

Virginia GOP Chairman Pat Mullins said such an image "has no place in our politics. Ever."

Loudoun County GOP chairman Mark Sell said in an email response to The Associated Press that the graphic was "a light-hearted attempt to inject satire humor into the Halloween holiday."

"Apparently, some individuals have interpreted an image of Barack Obama that appeared within the email as intending to portray the President as a victim of a violent crime," Sell wrote. "Nothing could be further from the truth, and we deeply and sincerely apologize to the President and anyone who viewed the image if that was the impression that was left."

There was no reply from Sell to a follow-up email seeking an alternative explanation for the nickel-sized hole in Obama's forehead.

The image was first reported in a post Monday on the conservative northern Virginia blog, Too Conservative. The post's author, identified as a "Loudoun Insider," said he's no Obama fan, "but putting up a photo of him as a zombie with a bullet hole in his head?"

"Someone should send this to the US Secret Service," the blog post concluded. The Secret Service is in charge of the president's security.

"We are aware of the situation," said George Ogilvie, a Secret Service spokesman in Washington.

The image the Loudoun GOP altered is the red, white and blue image of a determined-looking Obama gazing upward that, emblazoned with the caption "HOPE," became a ubiquitous Obama poster during his 2008 campaign.

It was created from a copyrighted AP photo taken in 2006 when Obama was a U.S. senator appearing at the National Press Club in Washington. The AP sued over the unlicensed, uncredited and uncompensated use of its photo. The litigation was settled earlier this year.

___

Online: http://bit.ly/utgv1l

Source: http://us.rd.yahoo.com/dailynews/rss/gop/*http%3A//news.yahoo.com/s/ap/20111031/ap_on_re_us/us_gop_zombie_obama

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US home video spending up for 1st time since 2008

In this 1977 image provided by 20th Century-Fox Film Corporation, from left, Harrison Ford, Carrie Fisher, and Mark Hamill are shown in a scene from "Star Wars" movie released by 20th Century-Fox. (AP Photo/20th Century-Fox Film Corporation)

In this 1977 image provided by 20th Century-Fox Film Corporation, from left, Harrison Ford, Carrie Fisher, and Mark Hamill are shown in a scene from "Star Wars" movie released by 20th Century-Fox. (AP Photo/20th Century-Fox Film Corporation)

(AP) ? Americans' spending on home videos has finally emerged from the recession ? helped by more purchases of higher-priced Blu-ray discs and greater outlays on cut-rate rentals from Netflix and Redbox.

For the three months through September, home movie spending rose nearly 5 percent from a year earlier to $3.9 billion, the first increase since early 2008, according to industry organization, The Digital Entertainment Group.

Buying digital copies of movies and ordering them from set-top box video-on-demand services also rose.

People bought fewer DVDs and made fewer trips to brick-and-mortar video rental stores, cutting into the gains.

For the year overall spending is down about 2 percent at $12.3 billion.

The industry is struggling to cope with a weak economic recovery and the gradual wane of the DVD era. The digital discs, once revolutionary for their clarity and durability, were shown the exit once Blu-ray became the industry's high-definition standard in 2008. Compared to a year ago, DVD sales dropped by 15 percent, or about $230 million, to $1.32 billion.

Blu-ray disc sales rose by about $156 million, to $423 million. That didn't make up for the DVD drop, even with the help of the popular re-release of the six "Star Wars" movies on Blu-ray, which racked up $38 million in North American in its first week of sales in late September.

There's still room for Blu-ray to grow. Although Blu-ray player households rose by 52 percent to 33.5 million, that's still only about a third of the TV-owning homes in the U.S.

Brick-and-mortar store rentals fell by $142 million to $353 million, but they were more than replaced by a $152 million gain in new delivery methods, such as online streaming, video-on-demand, mail-order subscriptions and cheap rentals from kiosks. Revenue from those rental methods rose to $1.70 billion. Kiosk rentals made up more than half of those gains.

Netflix Inc.'s price hike to customers on Sept. 1 may have bolstered the numbers, and Redbox said it was raising its nightly DVD rental fee to $1.20 from $1, which will likely add to the current quarter's totals.

The smallest segment remains digital purchases of movies, which rose by about $15 million to $136 million. Movie studios have been concerned that people aren't purchasing digital movies because they are worried the files won't be easily transferable to various devices, a concern it hopes to ease with its UltraViolet view-anywhere standard, which Warner Bros. launched this month.

Associated Press

Source: http://hosted2.ap.org/apdefault/495d344a0d10421e9baa8ee77029cfbd/Article_2011-10-31-Home%20Video%20Spending/id-ced24c3a05c04b23828268f1dc9b7207

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Obama cites income gap to push stalled jobs bill

President Barack Obama answers a reporter's question about the European debt deal as he meets with Czech Prime Minister Petr Necas, not shown, Thursday, Oct. 27, 2011, in the Oval Office of the White House in Washington. (AP Photo/Charles Dharapak)

President Barack Obama answers a reporter's question about the European debt deal as he meets with Czech Prime Minister Petr Necas, not shown, Thursday, Oct. 27, 2011, in the Oval Office of the White House in Washington. (AP Photo/Charles Dharapak)

A Whirlpool logo is seen on a Whirlpool appliance on the Singers showroom floor Thursday, Oct. 27, 2011 in Philadelphia. Appliance maker Whirlpool Corp. says it will cut 5,000 jobs in an effort as it faces soft demand and higher costs for materials. The jobs to be cut are mostly in North America and Europe. They include 1,200 salaried positions and the closing of the company's Fort Smith, Ark., plant. (AP Photo/Alex Brandon)

Vice President Joe Biden speaks at the Florida Democratic Party State Convention Friday, Oct. 28, 2011, in Lake Buena Vista, Fla. Vice President Joe Biden said he and President Barack Obama have made progress on fixing the problems they inherited from Republicans, but the GOP is using obstructionist tactics to keep the administration from doing more for the economy and middle class. (AP Photo/John Raoux)

(AP) ? President Barack Obama is banking on a new report detailing the income disparity in the country as further evidence of the need for his $447 billion jobs bill.

A report this past week by the Congressional Budget Office found that average after-tax income for the top 1 percent of U.S. households had increased by 275 percent over the past three decades. Middle-income households saw just a 40 percent rise. For those at the bottom of the economic scale, the jump was 18 percent.

Obama said in his weekly radio and Internet address Saturday that he would pay for his jobs plan with an added tax on people who make at least $1 million a year.

Senate Republicans have blocked action on the bill, which mixes tax breaks for businesses and public works spending, because they oppose much of the increased spending and the tax on millionaires.

"These are the same folks who have seen their incomes go up so much, and I believe this is a contribution they're willing to make," Obama said. "Unfortunately, Republicans in Congress aren't paying attention. They're not getting the message."

Obama is now trying to get Congress to pass the individual components of the bill. But Senate Republicans also stalled progress on the first of those measures, $35 billion to help local governments keep teachers on the job and pay the salaries of police officers, firefighters and other emergency services workers.

Saying the country cannot wait for Congress, Obama has begun bypassing Congress and taking steps on his own that he says will encourage economic growth.

On Friday, Obama directed government agencies to shorten the time it takes for federal research to turn into commercial products in the marketplace. The goal is to help startup companies and small businesses create jobs and expand their operations more quickly.

The president also called for creating a centralized online site for companies to easily find information about federal services. He previously had announced help for people who owe more on their mortgages than their homes are worth and for the repayment of student loans. The White House also challenged community health centers to hire veterans.

"We can no longer wait for Congress to do its job," Obama said. "So where Congress won't act, I will."

The congressional report, based on Internal Revenue Service and Census Bureau data, was released as the Occupy Wall Street movement spreading across the country protests bailouts for corporations and the income gap.

In the weekly GOP message, Illinois Rep. Bobby Schilling urged Obama to support bills that Republicans say would help create jobs by blocking various energy and environmental regulations and streamlining administrative procedures. The bills, passed by the Republican-controlled House, await action in the Democratic-run Senate.

Shilling said the bills give the White House and Congress an opportunity to build on the common ground created by the passage of recent free-trade agreements, and a measure to void a law requiring federal, state and many local governments to withhold 3 percent of their payments to contractors until their taxes are paid. Obama included repealing that tax in his jobs plan.

"Republicans have a jobs plan, one with some bipartisan support, but it's stuck in the Senate," said Schilling, owner of a pizza parlor in Moline, Ill. "We're asking President Obama to work with us and call on the Senate to pass the 'forgotten 15' to help the private sector create jobs, American jobs desperately needed."

___

Online:

Obama address: www.whitehouse.gov

GOP address: www.youtube.com/HouseConference

Associated Press

Source: http://hosted2.ap.org/APDEFAULT/3d281c11a96b4ad082fe88aa0db04305/Article_2011-10-29-Obama/id-eb5b92d6f5b84c369d3dd3734843304c

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Sunday, October 30, 2011

US consumer spending jumps 0.6 percent

(AP) ? Consumers boosted their spending in September at three times the pace of the previous month but their incomes barely budged. They financed the gains by saving at the lowest level since the start of the Great Recession.

The Commerce Department says consumer spending rose 0.6 percent in September, helped by a big rise in purchases of durable goods such as autos. But incomes rose only 0.1 percent after having fallen by the same amount in August. After adjusting for inflation, after-tax incomes fell 0.1 percent last month, the third straight monthly decline in after-tax incomes.

The savings rate fell to 3.6 percent. That's the lowest level since December 2007, just as the recession was beginning.

Associated Press

Source: http://hosted2.ap.org/APDEFAULT/f70471f764144b2fab526d39972d37b3/Article_2011-10-28-Consumer%20Spending/id-8630e4e7a2384c6baf4df4af809e9447

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Alabama immigration fight recalls civil rights era

FILE - In this Oct. 22, 2011 file photo, supporters surround Rep. Luis Gutierrez, D-Ill., center, as he leaves after speaking at the "Alabama United: One Family, One Alabama," mass rally in Birmingham, Ala. The rally called for a stand for the basic rights of all people. Now, in 2011, the epicenter of the fight over the nation's patchwork of immigration laws is not Arizona, which shares a border with Mexico and became a common site for boycotts. The case that's likely to be the first sorted out by the U.S. Supreme Court comes from the Deep South state of Alabama, where the nation's strictest immigration law has resurrected ugly images from Alabama's days as the nation's battleground for civil rights a half-century ago. And Alabama's jump to the forefront says as much about the country's evolving demographics as it does the nation's collective memory of the state's sometimes violent path to desegregation. (AP Photo/The Birmingham News, Tamika Moore, File) MAGS OUT; NO SALES

FILE - In this Oct. 22, 2011 file photo, supporters surround Rep. Luis Gutierrez, D-Ill., center, as he leaves after speaking at the "Alabama United: One Family, One Alabama," mass rally in Birmingham, Ala. The rally called for a stand for the basic rights of all people. Now, in 2011, the epicenter of the fight over the nation's patchwork of immigration laws is not Arizona, which shares a border with Mexico and became a common site for boycotts. The case that's likely to be the first sorted out by the U.S. Supreme Court comes from the Deep South state of Alabama, where the nation's strictest immigration law has resurrected ugly images from Alabama's days as the nation's battleground for civil rights a half-century ago. And Alabama's jump to the forefront says as much about the country's evolving demographics as it does the nation's collective memory of the state's sometimes violent path to desegregation. (AP Photo/The Birmingham News, Tamika Moore, File) MAGS OUT; NO SALES

FILE - In this May 3, 1963 file photo, a 17-year-old African American civil rights activist is attacked by police dogs during a demonstration in Birmingham, Ala. The epicenter of the fight over the nation's patchwork of immigration laws is not Arizona, which shares a border with Mexico and became a common site for boycotts. The case that's likely to be the first sorted out by the U.S. Supreme Court comes from the Deep South state of Alabama, where the nation's strictest immigration law has resurrected ugly images from Alabama's days as the nation's battleground for civil rights a half-century ago. And Alabama's jump to the forefront says as much about the country's evolving demographics as it does the nation's collective memory of the state's sometimes violent path to desegregation. (AP Photo/Bill Hudson, File)

FILE - In this April 12, 1963 file photo, Rev. Ralph Abernathy, left, and Rev. Martin Luther King Jr. lead a column of demonstrators as they attempt to march on Birmingham, Ala., city hall, however, police intercepted the group short of their goal. The epicenter of the fight over the nation's patchwork of immigration laws is not Arizona, which shares a border with Mexico and became a common site for boycotts. The case that's likely to be the first sorted out by the U.S. Supreme Court comes from the Deep South state of Alabama, where the nation's strictest immigration law has resurrected ugly images from Alabama's days as the nation's battleground for civil rights a half-century ago. And Alabama's jump to the forefront says as much about the country's evolving demographics as it does the nation's collective memory of the state's sometimes violent path to desegregation. (AP Photo/Horace Cort, File)

MONTGOMERY, Alabama (AP) ? The epicenter of the fight over the patchwork of immigration laws in the United States is not Arizona, which shares a border with Mexico and became a common site for boycotts. Nor was it any of the four states that were next to pass their own crackdowns.

No, the case that's likely to be the first sorted out by the U.S. Supreme Court comes from the Deep South state of Alabama, where the nation's strictest immigration law has resurrected ugly images from the state's days as the nation's battleground for civil rights a half-century ago.

And Alabama's jump to the forefront says as much about the country's evolving demographics as it does the nation's collective memory of the state's sometimes violent path to desegregation.

With the failure of Congress in recent years to pass comprehensive federal immigration legislation, Arizona, Georgia, Utah, South Carolina and Indiana have passed their own. But supporters and opponents alike agree none contained provisions as strict as those passed in Alabama, among them one that required schools to check students' immigration status. That provision, which has been temporarily blocked, would allow the Supreme Court to reconsider a decision that said a kindergarten to high school education must be provided to illegal immigrants.

Its stature as the strictest in the U.S., along with the inevitable comparisons of today's Hispanics with African-Americans of the 1950s and '60s, makes it a near certainty the law will be a test case for the high court.

"It really offers the Supreme Court a broad canvas to reshape what being an immigrant in the United States means," said Foster Maer, an attorney with LatinoJustice in New York, which is challenging the law.

Alabama was well-suited to be the nation's civil rights battleground because of its harsh segregation laws, large black population, and the presence of a charismatic young minister named Martin Luther King Jr., who led a boycott of segregated buses in 1955-56.

Opponents say the new law's schools provision conjures images of Gov. George Wallace's stand in the schoolhouse door to block racial integration.

"Today we have a different stand in the schoolhouse door. We have efforts to intimidate children who have a constitutional right to go to school," said Richard Cohen, president of the Southern Poverty Law Center.

Although no solid numbers exist, schools have reported fewer Hispanic students attending school, with some saying as much as 10 percent of their Hispanic students have withdrawn since the law took effect a month ago.

Illegal immigrants interviewed by The Associated Press have said their children were bullied and told to go back to Mexico, while others have described their intense fears of arrest and deportation.

The lawyer leading the state's defense, Alabama Attorney General Luther Strange, faults President Barack Obama's Justice Department for stirring the civil rights comparisons by falsely predicting the law would lead to the kind of widespread discrimination and profiling that marked Alabama's past.

"The idea they seem to have is there's a Bull Connor on every corner here in Alabama, which is so widely out of touch with our state," he said, referring to the public safety commissioner who unleashed police dogs and fire hoses on civil rights marchers in Birmingham in the 1960s.

At first glance, Alabama seems ill-suited to be the nation's immigration battleground. It's not a border state and is home to fewer illegal immigrants than several other Southern states.

"Why are we getting all the publicity? I think it has to do with Alabama's past and the perception that people have of Alabama over the years that don't live in our state and really don't recognize the amount of progress we've made in Alabama over the last 50 to 60 years," said Republican Gov. Robert Bentley, who supported the law and signed it into effect.

Alabama's law, pushed through by a new Republican super-majority in the state Legislature, is being challenged in federal court by the Justice Department, about 30 civil rights organizations and some prominent church leaders. Judges have blocked some provisions, but sections still stand that allow police to check a person's immigration status during traffic stops and make it a felony for illegal immigrants to conduct basic state business, like getting a driver's license.

State Rep. Alvin Holmes, the senior black member of the Legislature, said Republicans can't undo the voting rights gains of Democratic-leaning blacks, so they are going after brown-skinned people in hopes they won't gain a voting foothold. "They feel if these Hispanics come in and get registered to vote, they will team up with black voters to take over Alabama politics," he said.

Proponents say the law had nothing to with race. They say it was the result of frustration with the federal government's inaction and an effort to open up jobs for the nearly 10 percent of legal state residents out of work.

"There are people who try to make racism a cottage industry and profit off it, but I would put the harmony in Alabama up against any place in the country," said Republican Sen. Scott Beason, one of the law's sponsors.

Beason, the powerful chairman of the state Senate's Rules Committee, has prompted some of the comparisons with the civil rights era by telling one group that the Legislature needed to "empty the clip" on the immigration issue. And in tapes played during the federal trial of several lawmakers and lobbyists accused of buying and selling votes on gambling legislation, he referred to customers of a dog track in a predominantly black county as "aborigines."

Opponents of the law have fueled the comparisons by holding rallies at historic civil rights sites and drawing support from civil rights organizations.

No one in the Alabama Legislature was talking about immigration laws a decade ago because the Hispanic population was so small. The Pew Hispanic Center estimates the number of illegal immigrants in Alabama has grown from 25,000 in 2000 to 120,000 in 2010 ? a nearly fivefold increase ? though it's only a fraction of the 11 million or so estimated in the country.

That rapid rise drew complaints from residents who blamed Hispanics for knocking them out of jobs by working for cheaper wages and no benefits.

"They were coming in here like thieves in the night and taking our jobs and tax revenue," said Republican Rep. Micky Hammon, who also sponsored the new law.

To be sure, construction businesses and farms say Hispanic workers they have relied upon have fled the state. So far, they haven't been able to find legal residents willing to take on what is usually backbreaking work.

The governor said lawmakers in other states are eyeing Alabama's law as a blueprint for their own, but some fear that notoriety could come at a steep price: The state's image as an international automotive hub.

In 1993, a few months after state officials quit flying the secessionist Confederate Civil War battle flag on the Capitol dome, Mercedes selected Alabama for an assembly plant. Then came Honda, Toyota and Hyundai, and many auto suppliers.

The CEO of the state pension system, David Bronner, helped recruit those plants and now fears Alabama has hurt its ability to recruit.

"You are giving the image, whether it's valid or not, that you don't like foreigners, period," he said, adding that state leaders frequently seize on bad publicity to knock other states out of competition for new jobs.

That bad publicity has made its way to Hillsboro, Wisconsin, where information technology businessman Charles Manser and 11 of his buddies have canceled a 10-day golfing vacation to Alabama.

Manser said one friend was born in Puerto Rico and another is a British citizen. They were concerned about being hassled over their legal status.

"Whether it's legitimate or not, that's the message seen by people who might come to Alabama," he said.

Associated Press

Source: http://hosted2.ap.org/APDEFAULT/386c25518f464186bf7a2ac026580ce7/Article_2011-10-29-Alabama's%20Immigration%20Image/id-1fc718e148064f8db3565a4f6972724c

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An antibiotic effect minus resistance

Friday, October 28, 2011

After 70 years, antibiotics are still the primary treatment for halting the spread of bacterial infections. But the prevalence of antibiotic resistance is now outpacing the rate of new drug discovery and approval.

A microbiologist at the University of Wisconsin-Milwaukee (UWM) has discovered a different approach: Instead of killing the bacteria, why not disarm them, quashing disease without the worry of antibiotic resistance?

Ching-Hong Yang, associate professor of biological sciences, has developed a compound that shuts off the "valve" in a pathogen's DNA that allows it to invade and infect.

The research is so promising that two private companies are testing it with an eye toward commercialization.

"We analyzed the genomic defense pathways in plants to identify all the precursors to infection," says Yang. "Then we used the information to discover a group of novel small molecules that interrupt one channel in the intricate pathway system."

Yang and collaborator Xin Chen, a professor of chemistry at Changzhou University in China, have tested the compound on two virulent bacteria that affect plants and one that attacks humans. They found it effective against all three and believe the compound can be applied to treatments for plants, animals and people.

The work was published online this month in the journal Antimicrobial Agents and Chemotherapy.

Urgent concerns about antibiotics

The economic costs and health threats of antibiotic resistance have become so serious that the World Health Organization (WHO) this year dedicated World Health Day to call global attention to the issue.

Antibiotics are routinely sprayed on crops and widely used in factory farming of animals, which causes resistance to develop quickly. That antibiotic resistance is then transferred to humans who eat the food containing antibiotic-resistant bacteria.

Among the bacteria tested by the researchers is Pseudomonas aeruginosa, which is resistant to a broad range of antibiotics. It causes infections in people with compromised immune systems, such as HIV and cancer patients. It's also responsible for lung infections in patients with cystic fibrosis, and hospital-related infections such as urinary tract infections, pneumonia and infections from burns.

The fatality rate from these is about 50 percent. Hospital-acquired urinary tract infections by P. aeruginosa alone cost more than $3.5 billion a year in the U.S.

Road to the market

The research has attracted interest from two companies. Creative Antibiotics, a Swedish pharmaceutical company, is testing the compound and derivatives for human therapeutic uses and Wilbur-Ellis Agribusiness Division, based in Washington and California, is examining them for agricultural uses.

Despite the constant threat of disease in agriculture, says John Frieden, a biologist and R&D manager with Wilbur-Ellis, the industry has not had access to any new antibiotics in many years. U.S. regulatory agencies do not allow agribusiness to use antibiotics that are also used for human health ? even if they would be effective.

"The thing that caught my attention," Frieden says, "was that this was not an antibiotic, but it accomplishes the same thing as an antibiotic."

Although he says it is too soon to tell if a product could spring from the research, the approach is "incredibly unique. I've never seen anything that is even close to a commercial application like this. It could be very big."

The researchers have filed two patents on the work through the UWM Research Foundation (UWMRF), and Yang is partially funded through two UWMRF Bradley Catalyst Grants and a UWM Research Growth Initiative (RGI) grant.

Virulence factors

The compounds Yang and Chen have developed are unique because they take aim at one component of a cluster that makes pathogenic bacteria harmful.

One of those components, the type III secretion system (T3SS), gives pathogens their ability to invade a cell, letting in a host of proteins that enhance the bacterium's ability to cause disease.

"These bacteria are very smart," says Yang. "They grow a narrow appendage that acts as a 'needle,' injecting the virulence factors, such as toxins, into the host cell. The host cell cannot recognize the pathogen's 'needle,' so its defense mechanism is not triggered."

Yang and Chen's compounds block the production of T3SS. Although they have tested the compounds on only three pathogens, they have reason to believe the compounds will be effective against far more.

"T3SS exists in many different kinds of disease-causing bacteria," says Yang, "so the compounds can target multiple pathogens. That's the beauty of it."

He and his lab members are now working on developing more derivatives that could be effective against different kinds of harmful bacteria.

Yang also believes that their therapeutic compounds, like antibiotics, can offer both a broad spectrum of activity and be unique to a specific pathogen, depending on which virulence elements are targeted.

###

University of Wisconsin - Milwaukee: http://www.uwm.edu

Thanks to University of Wisconsin - Milwaukee for this article.

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Folate receptors may serve as a front door to ovarian cancer treatment

ScienceDaily (Oct. 28, 2011) ? A new strategy that takes advantage of ovarian cancer's reliance on folate appears to give relapse patients extra months of life with few side effects, researchers say.

The therapy uses the folate receptors on cancer cells as a sort of front door by pairing a substance attracted to the receptors with a chemotherapeutic agent too toxic to be given systemically, said Dr. Sharad Ghamande, Chief of the Section of Gynecologic Oncology at Georgia Health Sciences University.

Large numbers of folate receptors typically indicate the most aggressive ovarian cancers, as well as a variety of other cancers such as breast, lung and kidney.

The combination, called EC145, delivers a Vinca alkaloid directly inside cancer cells, improving effectiveness while reducing side effects particularly in women who overexpress folate receptors. A similar approach of pairing the folate ligand, which is attracted to the receptor, with a drug that makes those receptors glow, enables physicians to see how many folate receptors are present and who would be the best candidates for this treatment.

"We think this offers women with platinum-resistant disease a well-tolerated, effective treatment at a time when other drugs have failed them," Ghamande said. "We hope it will give them more quality time to meet important milestones, such as seeing a grandson graduate from high school." He noted that the strategy likely could enable targeted delivery of other drugs.

Ghamande is presenting findings of the phase 2 clinical trial at an Oct. 27-29 meeting in Brussels of the European Organisation for Research and Treatment of Cancer-National Cancer Institute-American Society of Clinical Oncology Annual Meeting on Molecular Markers in Cancer. The study enrolled 149 patients at 65 centers in North America and Poland; GHSU was among the top enrollers.

Platinum-based drugs are the standard of care for ovarian cancer, which is typically diagnosed in the late stages because there is no good screening test, such as the Pap smear for cervical cancer. After surgery and a round of chemotherapy, most women go into remission, but it's usually short-lived: about 70 percent of patients relapse within two years, Ghamande said. Physicians today often pair chemotherapeutic agents with biologic agents that bolster the immune response to try to improve outcomes. When women relapse or, inevitably, become platinum-resistant, they receive the chemotherapeutic agent Doxil.

The study compared, women receiving Doxil to those receiving Doxil as well as EC145. They found those with the most folate receptors on their cancer cells benefited the most from the new therapy: their progression-free survival went from 6.6 to 24 weeks, a 72 percent improvement from the standard therapy. "There is a proof of concept because the more folate receptors you overexpress, the better you do," Ghamande said.

Folate, or folic acid, is a B vitamin that is a basic component of cell metabolism and DNA synthesis and repair. Cancer cells, which are constantly multiplying and adapting, need more of it than healthy cells.

A larger Phase 3 study is underway internationally. The research was funded by Endocyte, Inc.

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The above story is reprinted from materials provided by Georgia Health Sciences University. The original article was written by Toni Baker.

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Source: http://www.sciencedaily.com/releases/2011/10/111028115340.htm

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Saturday, October 29, 2011

Republican proposes reshaping mortgage market (reuters)

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Health Watch: What Happens When Your Health Insurance ...

PHILADELPHIA (CBS) - Blood tests are vital for taking care of patients, and they?re usually covered by insurance. But what happens when the insurance company says no? 3 On Your Side Health Reporter Stephanie Stahl finds out and gets the problem solved.

Jorje Ann Laughlin depends on hormone replacement topicals for several conditions.

?It changed my life dramatically,? said Laughlin.

Along with the hormone prescription comes a script for regular blood tests. It?s the only way the doctor can accurately monitor hormone levels that fluctuate and often need adjusting.

The tests had been routinely covered by Laughlin?s insurance company, Aetna. But in February, Laughlin received a bill for $176.00 for a blood test. Aetna first said it wasn?t covered, then there was a paperwork problem, then too much time passed.

Stephanie asked, ?They had paperwork saying that it was supposed to be covered. The doctor said it was medically necessary, and they keep saying no??
Laughlin said, ?Financially it would have been a real burden to have to pay that.?

?It can be overwhelming at times,? said Dr. John McGeehan, an Internist with Cooper University Hospital. He says doctors depend on blood tests to diagnose and monitor many conditions. And he says they?re usually paid for by insurance companies.

?My experience has been they will always be covered if that slip is filled out appropriately,? said Dr. McGeehan.

Laughlin says she had all the necessary paperwork, but she still spent months on the phone fighting about the bill. Being 65 and on a fixed income, she says there?s no way she could pay the $176.00 bill.

?I just thought it was so unfair to be treated like that. How can they issue a policy, you follow it, the doctor follows it, and they can say they don?t want to cover it?? said Laughlin.

With her credit rating on the line, Laughlin called 3 On Your Side. And we called Aetna. Days later we got a response from Aetna.

?After hearing from you, we looked at all of it again and went ahead with the second appeal. And they?ve decided to overturn their denial. So they?re going to pay for it,? reporter Stephanie Stahl told Laughlin.

?I?m glad you guys are out there being for the people,? said Laughlin.

Aetna also said after 3 On Your Side got involved they were able to get more information from Laughlin?s doctor.

Experts say people need to know that you can and should stand up to insurance companies, if it appears there?s a mistake. It?s up to the policy holder to check and follow up.

Reported by Stephanie Stahl, CBS 3

MOST VIEWED ON?CBSPHILLY

Source: http://philadelphia.cbslocal.com/2011/10/28/health-watch-what-happens-when-your-health-insurance-company-says-no/

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PFT: Palmer 'can't see' T.O. in Oakland

Chicago Bears v Tampa Bay BuccaneersGetty Images

We?re checking in with teams as they hit their bye week. ?Or at least we are trying to.

Next up: The Chicago Bears.

Familiar position

Lovie Smith told everyone to calm down after the team?s loss to the Lions on Monday Night Football in Week 5. ?He pointed out that if the team could beat the Vikings and Bucs, they would be 4-3 just like last year at the bye.

Give Smith credit: That?s exactly what happened. ?After a?tumultuous?training camp and start to the season, the Bears are in decent enough shape.

The Bears season has a different feel to it after two strong efforts. They completely destroyed Minnesota, and controlled the action against the Bucs in London.

The Bears have proven capable of beating mediocre competition. They can?t beat the best NFC teams: The Packers, Saints, and Lions all have wins over Chicago.

Forte leads the way

Adrian Peterson is the best running back in the NFL. ?Matt Forte may be the most important to his team. ?Forte leads all players by a wide margin in yards from scrimmage with 1,091. ?He is just off Chris Johnson?s all time yards from scrimmage record pace.

It?s hard to overstate how good Forte is as a receiver. He has a shot to be the first running back since Marshall Faulk to put up over 1,000 rushing yards and 1,000 receiving yards in the same season. It?s no coincidence Mike Martz was involved in both seasons.

Improving passing game

Jay Cutler may have enjoyed the best two game stretch of his Bears career in the loss to the Lions and the win over the Vikings. He is looking more comfortable. His pass protection has improved from absymal to simply lame.

The offense still has to be more consistent after some early ugly outings, but it?s headed in the right direction. It?s 12th in scoring despite the 21 sacks Cutler has taken. The team has a +4 turover margin.

Safety dance

Chris Harris started the season at strong safety; he was released Thursday. Brandon Meriweather was signed for $3.25 million and now sits on the bench. The team is going young with Major Wright and Chris Conte at the position. ?This is a shaky secondary overall.

Average defense

Lovie Smith teams are supposed to be built on defense. At this stage, the Bears have been ordinary stopping opponents. Lance Briggs and Brian Urlacher are still playing at a high level, but they don?t get a lot of help. The defensive line has been decent. Julius Peppers has played at less than 100%.

Chicago?s only chance to make a postseason push is for the defense to improve dramatically.

Angling for a wild card

The Bears are three games back in the NFC North, so their only hope for a playoff spot is a wild card. They are in decent shape with wins over NFC contenders like Atlanta and Tampa Bay.

The next two weeks after the bye are huge. ?The Bears travel to Philadelphia before hosting Detroit. Sweeping those two games would put Chicago in terrific position before an oddly timed four-game tour through the AFC West.

After seven weeks, the Bears are in the mix. Their recent play indicates we?ll probably be talking about Bears tiebreakers come late December.

Source: http://profootballtalk.nbcsports.com/2011/10/26/carson-palmer-cant-see-t-o-coming-to-oakland/related/

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Friday, October 28, 2011

Christina Perri Calls 'Breaking Dawn' Video 'Dream-Like'

Singer says 'A Thousand Years,' her contribution to the 'Twilight' soundtrack, is 'about the simplest kind of love and a timeless love.'
By Jocelyn Vena


Christina Perri in her "A Thousand Years" music video
Photo: Atlantic

Christina Perri's video for her "Twilight" soundtrack tune, "A Thousand Years," hit the streets this week — in anticipation of all things "Breaking Dawn - Part 1" going down in November — and Twilighters won't be disappointed.

The video for the romantic tune is a mix of footage from the film, including the wedding scene and all that honeymoon hotness, as well as footage of Perri decked out in a gown, singing the passionate lyrics of the song while surrounded by candles.

MTV News was on the "A Thousand Years" video set, where the singer opened up about her fandom for "The Twilight Saga."

"I wrote [the song] for Edward and Bella in their perspective," Perri explained, calling the song "pretty, classical and simple." "It's the purest love song I think I could have possibly written. It's about the simplest kind of love and a timeless love.

"I've been a really big 'Twilight' fan for years. For me, it just has to do most with the love story between Edward and Bella. I feel like it's 'Romeo and Juliet,' and they just happen to be vampires and there's werewolves. I loved the story from day one."

Perri said that being such a "Twilight" fan makes having her song on the soundtrack that much more meaningful. "The fact that my dream came true ... still blows my mind, and I don't think I've fully processed it yet, even though we're on the set of the music video," she said. "I feel like maybe when we're at the premiere and I see it in the movie is when it'll really hit me because it just seems so dream-like. I feel so honored. It feels really epic."

The album hits stores November 8, just 10 days before the Bill Condon-directed "Breaking Dawn" opens November 18. A video for Bruno Mars' track, "It Will Rain," is slated to drop "in a couple weeks," Mars tweeted Monday. The last part of the "Twilight Saga," "Breaking Dawn - Part 2," opens November 2012.

Check out everything we've got on "The Twilight Saga: Breaking Dawn - Part 1."

For young Hollywood news, fashion and "Twilight" updates around the clock, visit HollywoodCrush.MTV.com.

Related Videos

Source: http://www.mtv.com/news/articles/1673174/christina-perri-thousand-years-breaking-dawn-video.jhtml

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Charlie Sheen's 'Anger Management' Show To Air On FX

Series based on Adam Sandler movie of the same name will debut next summer.
By Gil Kaufman


Charlie Sheen
Photo: Michael Buckner/ Getty Images

Charlie Sheen promised that we hadn't seen the last of him. The excitable, unpredictable former "Two and a Half Men" star has finally found a home for his new series, "Anger Management." The show will start airing on FX next summer, according to The Hollywood Reporter. And in a truly Sheen-ian twist, his new program will be paired with reruns of "Men," the show Sheen was booted from earlier this year after a ratings-bonanza eight-season run due to his erratic behavior.

The new show is based on the 2003 movie of the same name that starred Adam Sandler as Dave Buznik, a man wrongly sentenced to anger management classes after an incident on a plane. His issues are only exacerbated by his therapist, Dr. Buddy Rydell (Jack Nicholson), who eggs Dave on to even more aggressive acts. Sheen will reportedly play the Nicholson role.

Three cable networks reportedly bid on the Sheen show, which will take the air alongside such edgy FX fare as the downbeat comedy "Louie" and the man-and-his-imaginary-talking-dog sitcom "Wilfred." Sheen's team will begin writing scripts and casting for the first 10 episodes right away, and if those initial shows do well, another 90 may be ordered.

Though Sheen famously clashed with Chuck Lorre, the veteran TV exec who ran "Men," Chuck Lorre, he will be working with another long-timer on his new project, show runner Bruce Helford, who has logged time on "Roseanne," "George Lopez" and "The Drew Carey Show."

"We think that Bruce Helford, [producer] Joe Roth and Charlie Sheen have come up with a wonderful, hilarious vehicle for Charlie's acting talents — and a character we are very much looking forward to seeing him play," John Landgraf, president and general manager of FX Networks, said in a statement announcing the deal on Thursday. " 'Two and a Half Men' has been an outstanding component of FX's schedule for the past 14 months, and we have every confidence that 'Anger Management' will soon be as well."

Sheen suffered a well-publicized hospitalization and brief return to rehab earlier this year and a subsequent jag of erratic, unhinged media appearances that resulted in his booting from "Men." But he has settled down as of late, appearing at a Comedy Central roast in his honor and offering kind words for his "Men" successor, Ashton Kutcher.

Source: http://www.mtv.com/news/articles/1673333/charlie-sheen-show-anger-management-fx.jhtml

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Daimler net profit slips to $1.9 billion

(AP) ? German automaker Daimler AG said net profit fell 16 percent in the third quarter to euro1.36 billion ($1.9 billion) as a troubled economy in Europe and model changeover costs held back earnings at its mainstay Mercedes-Benz division.

Company revenue rose 9 percent to euro26.4 billion ($36.8 billion) and the Mercedes division hit a record for unit sales in the quarter with 315,400 worldwide.

But the company pointed to growing headwinds from Europe's debt crisis and an increasingly unstable global economic environment.

For the company as a whole, revenue from Western Europe rose a bare 1 percent and fell by 2 percent in the United states.

"In Western Europe ... there is little sign of any significant growth impetus," the company said Thursday in the earnings report, citing the impact on confidence of the crisis over too much debt in some European countries.

Emerging markets are seeing slowing and more uneven growth as central banks in those countries raise interest rates to combat inflation, the company said. China's auto market continues to grow, but vehicle registrations fell in India and growth slowed in Brazil.

Earnings from Mercedes-Benz, measured before interest and taxes, fell 15 percent to euro1.11 billion due to "a number of factors with negative impact on earnings." Those included upcoming model changeovers, higher raw-material costs, and increases in research and development expenses.

CEO Dieter Zetsche, who also heads the Mercedes division, said the company remained on course and reaffirmed its profit target for the year, saying operating earnings would show a "very significant" increase over last year.

"Daimler operated very successfully also in the third quarter," Zetsche said in a statement. "All the divisions are pursuing their goals very consistently and are right on track."

The company missed estimates from analysts surveyed by Factset of euro1.40 billion, in part because it took a writedown of euro110 million ($153 million) for its investment in Renault and another, euro23 million ($32 million) charge for its investment in Russia's Kamaz because both companies' share prices have taken a sharp fall.

Analyst Max Warburton at Bernstein Research wrote that "these are solid results, but obviously slightly light versus consensus."

He said Mercedes profit margins were good at over 8 percent but after 10 percent in the first half, "they're not standout" ? especially as competitors BMW AG and VW's Audi run at double-digit margins.

Mercedes sold a record 337,200 vehicles globally in the quarter, but upcoming model changes in the B-Class and M-Class models held sales in Western Europe below last year's level, and sales in the U.S. came in 200 units under last year's level of 55,100. China showed strong growth, as that market passed the United States in unit sales with 56,000 vehicles, up from 39,200 the year before.

The company said the global economy was still growing but had entered "rough waters" marked by sudden swings on financial markets and concerns about high levels of government debt in the U.S. and the euro currency zone that were weighing on confidence. Europe's debt crisis and attempts to cut government spending in indebted countries "are an increasing burden on economic developments."

Eurozone leaders arrived at a deal early Thursday to reduce Greece's debt by having banks holding the country's bonds take larger losses, but spending reductions in Greece and other countries with high debts such as Ireland, Portugal, and Spain continue to weigh on those economies.

(This version CORRECTS writedown figures for Renault and Kamaz.)

Associated Press

Source: http://hosted2.ap.org/APDEFAULT/f70471f764144b2fab526d39972d37b3/Article_2011-10-27-EU-Germany-Earns-Daimler/id-f3fef29c5547411b8791b57652628950

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Thursday, October 27, 2011

Rise in Medicare premiums less than feared in 2012 (AP)

WASHINGTON ? Medicare's basic monthly premium will rise significantly less than expected next year, the government announced Thursday. That could pay political dividends for President Barack Obama and for Democrats struggling to win over seniors in a close election.

The new Part B premium for outpatient care will be $99.90 a month for 2012, or about $7 less than projected as recently as May.

The bottom line: most seniors will pay an additional $3.50 a month next year, instead of $10.20, as forecast earlier.

Some younger retirees who enrolled recently have been paying up to $115.40 a month. Instead, they'll get a sizable break next year.

Premiums have been frozen at the 2008 level of $96.40 a month for about three-fourths of Medicare beneficiaries. That was due to the lack of a Social Security cost-of-living adjustment during the depths of the economic downturn. But Social Security recently announced a raise in monthly checks averaging $39 for 2012.

The Medicare news means the majority of seniors will have to fork over only a small part of their long-awaited COLA for premiums.

The reason for the lower-than-expected premiums has to do with the interaction between Social Security COLAs and Medicare premiums. But the Obama administration is hoping seniors will get a simple takeaway message: Medicare is under sound management.

Older voters went decisively for Republicans in the 2010 elections, after Obama's health care overhaul law cut Medicare spending to help finance coverage for uninsured working-age adults and their families.

Since then, the administration has doubled down to try to reverse any perception that Obama is steering Medicare into decline.

Earlier this year, officials had announced that premiums for Medicare's prescription benefit would remain unchanged for 2012, on average. Similarly, average premiums for popular Medicare Advantage plans will dip slightly in 2012. But those announcements do not have as much impact. Averages used by the government don't reflect individual experiences. And fewer beneficiaries are enrolled in either of those two benefits.

The Part B premium is one number that most of the 49 million people on Medicare can connect with.

Upper-income retirees pay more, and premiums for low-income beneficiaries are covered by Medicaid. But middle-class beneficiaries on tight budgets watch the Part B figure.

In a statement accompanying release of the Medicare premiums, Health and Human Services Secretary Kathleen Sebelius asserted that seniors have nothing to fear from the new health care law.

"The Affordable Care Act is helping to keep Medicare strong and affordable," she said. "People with Medicare are seeing higher quality benefits, better health care choices and lower costs."

A leading nonpartisan expert on Medicare said she doubted election-year politics are behind the lower-than-expected premiums for 2012.

"Changes in premiums are obviously important to seniors but the numbers are based on what the law requires, and determined by independent actuaries, rather than politics," said Tricia Neuman of the Kaiser Family Foundation.

Neuman said the explanation is likely due to the complicated relationship between Social Security COLAs and Medicare premiums.

By law, the Part B premium is set to cover 25 percent of the cost of Medicare's outpatient care benefit.

But premiums have been frozen for most beneficiaries in recent years because federal law also says that ? with some exceptions ? an individual's Medicare premium cannot go up more than their Social Security COLA.

That left a relatively small share of beneficiaries, including recent enrollees, bearing the brunt of higher Medicare costs. Indeed, the so-called "standard premium" for 2011 rose to $115.40.

Back in May, when government experts originally forecast a premium of $106.60 for 2012, they were also projecting a Social Security COLA of just 0.7 percent. But the final COLA increase turned out to be much bigger, a 3.6 percent raise. And that meant rising Medicare costs could be spread among many more people, resulting in smaller increases for each individual.

"It has been an odd several years because of what has been going on with the COLA," said Neuman. "Not everybody was paying in the standard amount. Because more people are contributing, the effect of that is that the amount should go down."

Indeed, baby boomers who signed up for Medicare this year and were paying $115.40 a month will save $15.50 a month next year, an annual total of $186.

HHS also said the 2012 premium figure takes into account a fix for the biggest problem hanging over Medicare. Unless Congress acts by the end of the year, doctors will be hit with a 30 percent pay cut. But the department said since Congress is almost certain to override that cut, the cost of keeping doctors whole has been factored in to the premium calculations.

Medicare's Part B annual deductible, the amount beneficiaries pay before their coverage begins, will also drop next year to $140, a decrease of $22.

___

Associated Press writer Stephen Ohlemacher contributed to this report.

Source: http://us.rd.yahoo.com/dailynews/rss/obama/*http%3A//news.yahoo.com/s/ap/20111027/ap_on_go_ca_st_pe/us_medicare_premiums

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Ultrasound viewing part of NC abortion law blocked (Providence Journal)

Share With Friends: Share on FacebookTweet ThisPost to Google-BuzzSend on GmailPost to Linked-InSubscribe to This Feed | Rss To Twitter | Politics - Top Stories Stories, News Feeds and News via Feedzilla.

Source: http://news.feedzilla.com/en_us/stories/politics/top-stories/153338548?client_source=feed&format=rss

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Charlie Sheen Sends Best Wishes to Patrice O'Neal


Two days after comedian Patrice O'Neal suffered a massive stroke, Charlie Sheen has sent his best wishes for a full recovery to one of the celebrities who roasted him last month.

Charlie Sheen Roast PosePatrice O'Neal Photo

"[Patrice] is a gentle giant, a brilliant comedian, and a noble dude. Wishing him nothing but recovery, healing and laughter," Sheen told TMZ.

Dane Cook, a Boston native like O'Neal, also took to Twitter to pay tribute to the funny man, writing:

“Please pray for him and his family. Patrice is unlike anyone I’ve ever met. He’s one of the best comedians ever. Period. He also gave me some of the most useful/real (expletive) advice I’ve ever received. Please put positive thoughts into this world for P. #hope.”

[Photos: WENN.com]

Source: http://www.thehollywoodgossip.com/2011/10/charlie-sheen-sends-best-wishes-to-patrice-oneal/

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Compound found in common wart treatment shows promise as leukemia therapy

Compound found in common wart treatment shows promise as leukemia therapy [ Back to EurekAlert! ] Public release date: 26-Oct-2011
[ | E-mail | Share Share ]

Contact: Stacey May
MayS@aaps.org
703-459-7677
American Association of Pharmaceutical Scientists

Research to be featured at 2011 AAPS Annual Meeting and Exposition

Arlington, Va. -- A new potential leukemia therapy targets only cancer cells, while leaving healthy cells alone. Many current chemotherapy treatments affect cancer cells and healthy cells, causing significant side effects, such as fatigue, hair loss, nausea, anxiety and depression. This research is being presented at the 2011 American Association of Pharmaceutical Scientists (AAPS) Annual Meeting and Exposition in Washington, D.C., Oct. 23 27.

Leukemia is a cancer of the blood and bone marrow, the spongy center of bones where blood cells are formed. According to the Leukemia and Lymphoma Society, an estimated 43,050 people were diagnosed with leukemia in the U.S. in 2010.

Lead researcher and AAPS fellow, Peter A. Crooks, Ph.D., and his colleagues from the University of Arkansas for Medical Sciences have developed a potent compound that only impacts cancer cells, and starts killing them as early as four hours after treatment begins.

"This is one of the most potent and selective compounds I have ever seen during my more than 30-year career," said Crooks.

The molecules used to create this anti-leukemic agent are structurally similar to the compound found in many gout treatments and over-the-counter products used to treat warts, which also prevent cell growth. This agent is able to reach cancer cells before they mature, so catching the disease in its early stages will eradicate it quickly. This is especially vital for treating acute myeloid leukemia, which progresses rapidly without treatment.

"It's good to get excited in the early stages of research when you discover a treatment that could potentially be as outstanding as this," said Crooks. "However, the next phase is to test the treatment in animal models and pinpoint the most effective delivery method."

###

The AAPS Annual Meeting and Exposition, the world's largest pharmaceutical sciences meeting aims to improve global health through advances in pharmaceutical sciences. AAPS, currently celebrating its 25th anniversary, has themed the keynote and plenary sessions at this year's Annual Meeting "The Next 25 Years." An estimated 9,000 scientists from around the world will participate in 90 sessions, including more than 60 symposia and roundtables.

Learn more about the meeting and global health from leading scientists in this webisode series and follow the tweet hashtag #AAPS2011 for meeting updates.

Editor's Note: All press must register and provide press credentials to attend this meeting. To register, please contact MayS@aaps.org or 703-248-4740 prior to the meeting or visit room 149A during the conference. To schedule an interview with Peter Crooks or any other press inquiry, please contact Hillarie Turner at hbt@ecius.net or 202-296-2002 x113.

About AAPS: The American Association of Pharmaceutical Scientists is a professional, scientific society of approximately 12,000 members employed in academia, industry, government and other research institutes worldwide. For more information, please visit http://www.aaps.org.



[ Back to EurekAlert! ] [ | E-mail | Share Share ]

?


AAAS and EurekAlert! are not responsible for the accuracy of news releases posted to EurekAlert! by contributing institutions or for the use of any information through the EurekAlert! system.


Compound found in common wart treatment shows promise as leukemia therapy [ Back to EurekAlert! ] Public release date: 26-Oct-2011
[ | E-mail | Share Share ]

Contact: Stacey May
MayS@aaps.org
703-459-7677
American Association of Pharmaceutical Scientists

Research to be featured at 2011 AAPS Annual Meeting and Exposition

Arlington, Va. -- A new potential leukemia therapy targets only cancer cells, while leaving healthy cells alone. Many current chemotherapy treatments affect cancer cells and healthy cells, causing significant side effects, such as fatigue, hair loss, nausea, anxiety and depression. This research is being presented at the 2011 American Association of Pharmaceutical Scientists (AAPS) Annual Meeting and Exposition in Washington, D.C., Oct. 23 27.

Leukemia is a cancer of the blood and bone marrow, the spongy center of bones where blood cells are formed. According to the Leukemia and Lymphoma Society, an estimated 43,050 people were diagnosed with leukemia in the U.S. in 2010.

Lead researcher and AAPS fellow, Peter A. Crooks, Ph.D., and his colleagues from the University of Arkansas for Medical Sciences have developed a potent compound that only impacts cancer cells, and starts killing them as early as four hours after treatment begins.

"This is one of the most potent and selective compounds I have ever seen during my more than 30-year career," said Crooks.

The molecules used to create this anti-leukemic agent are structurally similar to the compound found in many gout treatments and over-the-counter products used to treat warts, which also prevent cell growth. This agent is able to reach cancer cells before they mature, so catching the disease in its early stages will eradicate it quickly. This is especially vital for treating acute myeloid leukemia, which progresses rapidly without treatment.

"It's good to get excited in the early stages of research when you discover a treatment that could potentially be as outstanding as this," said Crooks. "However, the next phase is to test the treatment in animal models and pinpoint the most effective delivery method."

###

The AAPS Annual Meeting and Exposition, the world's largest pharmaceutical sciences meeting aims to improve global health through advances in pharmaceutical sciences. AAPS, currently celebrating its 25th anniversary, has themed the keynote and plenary sessions at this year's Annual Meeting "The Next 25 Years." An estimated 9,000 scientists from around the world will participate in 90 sessions, including more than 60 symposia and roundtables.

Learn more about the meeting and global health from leading scientists in this webisode series and follow the tweet hashtag #AAPS2011 for meeting updates.

Editor's Note: All press must register and provide press credentials to attend this meeting. To register, please contact MayS@aaps.org or 703-248-4740 prior to the meeting or visit room 149A during the conference. To schedule an interview with Peter Crooks or any other press inquiry, please contact Hillarie Turner at hbt@ecius.net or 202-296-2002 x113.

About AAPS: The American Association of Pharmaceutical Scientists is a professional, scientific society of approximately 12,000 members employed in academia, industry, government and other research institutes worldwide. For more information, please visit http://www.aaps.org.



[ Back to EurekAlert! ] [ | E-mail | Share Share ]

?


AAAS and EurekAlert! are not responsible for the accuracy of news releases posted to EurekAlert! by contributing institutions or for the use of any information through the EurekAlert! system.


Source: http://www.eurekalert.org/pub_releases/2011-10/aaop-cfi102411.php

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