Wednesday, May 15, 2013

Google CEO says vocal cords affected by "very rare" condition

By Alexei Oreskovic

SAN FRANCISCO (Reuters) - Google Inc Chief Executive Larry Page provided the first public details of the voice ailment that sidelined him from speaking engagements last summer, saying that he has limited movement in his left and right vocal cords.

The 40-year-old co-founder of the world's No. 1 Internet search engine said that doctors have been unable to identify a cause for the "very rare" nerve problems affecting his vocal cords, but that he has been making progress in his recovery and is "fully able to do all I need to at home and at work," he wrote on his Google+ page on Tuesday.

Page also said his voice is now "softer" than before, making it difficult to deliver long monologues. Since vocal cord nerve conditions can also affect breathing, his ability to exercise at "peak aerobic capacity" is reduced, though he noted that he continues to enjoy kitesurfing.

He also said that he had been diagnosed with Hashimoto's thyroiditis in 2003, which he described as a "fairly common inflammatory condition of the thyroid which causes me no problems." Page said it was unclear if this is a factor in his vocal cord condition or if both conditions were triggered by a virus.

News of Page's voice condition caused some consternation among investors when it was disclosed last summer, particularly because the company provided few details other than noting he had "lost his voice." But while Page is considered key to Google's success, his health does not appear to have become an issue of widespread concern on Wall Street.

Page, who co-founded Google with Sergey Brin in 1998, reclaimed the CEO title in April 2011 after a decade under the stewardship of Eric Schmidt. Shares of Google have surged roughly 50 percent since Page took the reins, compared to a 23 percent rise in the Dow Jones industrial average during the same period.

Google is due to hold its annual developer conference in San Francisco beginning on Wednesday. It is not clear if Page will speak at the event, which he could not address last year because of the voice condition.

Google controls roughly two-thirds of the world's Internet search market and its Android smartphone operating system is the world's most popular mobile phone software.

Under Page's leadership, the company has also pulled the plug on products that were not meeting expectations and pushed the company to focus on ambitious "big bets," such as wearable computer glasses and self-driving cars.

The voice problems started about 14 years ago, Page explained on Tuesday, when after suffering a bad cold, he was diagnosed with left vocal cord paralysis.

"Fast forward to last summer, when the same pattern repeated itself ? a cold followed by a hoarse voice," Page said. "Once again, things didn't fully improve, so I went in for a checkup and was told that my second vocal cord now had limited movement as well," he explained.

Page said he has arranged to fund a significant research program through the Voice Health Institute, which will be led by one of the doctors that he has consulted for his condition.

Shares of Google, which have traded at all-time highs in recent weeks, were last up 0.98 percent at $886.11.

(Reporting by Alexei Oreskovic, editing by G Crosse)

Source: http://news.yahoo.com/google-ceo-says-vocal-cords-affected-very-rare-182640834.html

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Possible new acute leukemia marker, treatment target identified

May 13, 2013 ? A study has identified microRNA-155 as a new independent prognostic marker and treatment target in patients with acute myeloid leukemia that has normal-looking chromosomes under the microscope (that is, cytogenetically normal acute myeloid leukemia, or CN-AML).

The study was led by researchers at the Ohio State University Comprehensive Cancer Center -- Arthur G. James Cancer Hospital and Richard J. Solove Research Institute (OSUCCC -- James). The researchers found that when microRNA-155 (miR-155) is present at abnormally high levels in CN-AML cells, patients are less likely to have a complete remission, and they experience a shorter disease-free period and shorter overall survival. The effect is independent of other known prognostic gene mutations present in the cells.

Published in the Journal of Clinical Oncology with an accompanying editorial and an "Understanding the Pathway" article, the findings suggest that miR-155 plays a pivotal role in CN-AML development, and that it could be a valuable target for the emerging class of drugs designed to inhibit microRNAs, says first author Dr. Guido Marcucci, professor of hematology, a leukemia specialist and associate director for Translational Research at the OSUCCC -- James.

"MiR-155 would be relatively easy to measure at the time of diagnosis," Marcucci says. "We believe it will prove to be a good marker for stratifying patients according to recurrence risk and a good target for emerging compounds designed to inhibit microRNAs."

Principal investigator Dr. Clara D. Bloomfield, Distinguished University Professor and Ohio State University Cancer Scholar and Senior Advisor and William Greenville Pace III Endowed Chair in Cancer Research notes that, "Overall, our findings indicate that miR-155 expression is a strong and independent prognostic marker in CN-AML, and they provide clinical validation of data from preclinical models that support a crucial role of miR-155 in leukemia."

The researchers also note that because a molecule called NF-kB is believed to regulate miR-155, treatments that inhibit that molecule might also help patients with high miR-155 levels.

Cells use microRNA molecules to help regulate the kinds and amount of proteins they make. Abnormal levels of certain microRNAs are likely to play a key role in cancer development. Abnormally high expression of miR-155 is associated with lymphoma, aggressive chronic leukemias and certain solid tumors, and microRNA levels have been associated with patient survival.

For this study, Marcucci, Bloomfield and their colleagues analyzed bone-marrow or blood specimens from 363 CN-AML patients, 153 of whom were under age 60 and 210 were age 60 and over. All were treated on Cancer and Leukemia Group B (CALGB) clinical trials.

The researchers evaluated the association of abnormal miR-155 expression levels with clinical and molecular characteristics and with disease-free survival and overall survival.

The study's key technical findings include:

  • Overall, patients with high miR-155 expression were about 50 percent less likely to achieve complete remission, and to have a 60 percent increase in the risk of death compared to patients with low miR-155 expression.
  • High miR-155 expression was associated with pro-survival, proliferation and inflammatory gene activity, suggesting a pivotal role in leukemia development.
  • In patients under age 60, higher miR-155 expression was associated with a lower complete response rate, and shorter disease-free survival and overall survival; in older patients, higher miR-155 expression was associated only with a lower complete response rate and shorter overall survival.
  • The difference between older and younger patients may be related to differences in the intensity of consolidation therapy administered to younger versus older patients, as well as to biological differences.

Funding from the NIH/National Cancer Institute (grants CA101140, CA114725, CA31946, CA33601, CA16058, CA77658, CA129657 and CA140158), The Coleman Leukemia Research Foundation, the Deutsche Krebshilfe-Dr Mildred Scheel Cancer Foundation, the Pelotonia Fellowship Program and the Conquer Cancer Foundation supported this research.

Other researchers involved in this study were Klaus H. Metzeler, Stefano Volinia, Yue-Zhong Wu, Krzysztof Mr?zek, Susan P. Whitman, Jason H. Mendler, Sebastian Schwind, Heiko Becker, Ann-Kathrin Eisfeld, Ramiro Garzon and Michael A. Caligiuri of The Ohio State University; Kati Maharry, Deedra Nicolet and Jessica Kohlschimdt of Ohio State and of the Alliance for Clinical Trials in Oncology Statistics and Data Center; Andrew J. Carroll of University of Alabama at Birmingham; Bayard L. Powell of Wake Forest University; Jonathan E. Kolitz of Monter Cancer Center; and Richard M. Stone of Dana Farber Cancer Institute.

Source: http://feeds.sciencedaily.com/~r/sciencedaily/top_news/top_health/~3/lnHaUgfJ0lY/130513131509.htm

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Tuesday, May 14, 2013

Syria wants details about US-Russian initiative

DAMASCUS, Syria (AP) ? Syria's information minister says Damascus needs more details about a proposed U.S.-Russian initiative before it decides whether to attend. The main opposition group has taken a similar stand.

Omran al-Zoubi says in remarks carried by state news agency SANA Tuesday that Syria will not take part in any political dialogue that infringes on the country's sovereignty.

The U.S. and Russia called last week for an international conference to start talks accompanied by a cease-fire. The two nations are on opposite sides of the Syria conflict. This marks their first serious joint attempt at Syria diplomacy in a year.

Syria's Foreign Ministry welcomed the U.S.-Russian initiative without saying whether it would attend.

The main opposition bloc, the Syrian National Coalition, said Monday it wants to consult its allies before deciding.

Source: http://news.yahoo.com/syria-wants-details-us-russian-initiative-081544903.html

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Centres to drive UK space activity

Two major elements in Britain's space strategy have been officially unveiled in Oxfordshire.

One is the European Space Agency's (ESA) first technical centre in the UK, to be known as the European Centre for Space Applications and Telecoms.

The other is the Satellite Applications Catapult, one of seven new government initiatives intended to drive innovation in growing areas of the British economy.

Both centres are on the Harwell campus.

Their co-location is quite deliberate. The Oxfordshire science park, most visible for its giant Diamond synchrotron facility, is already home to a lot of space activity, not least the Rutherford Appleton Laboratory, which builds and tests satellite equipment.

"We see Harwell as a campus which is going to provide a combination of world-class science, high-tech activity, and business opportunity," said David Willetts, the UK's science minister.

"One of the reasons why Esa have been so keen to have a stronger presence here is precisely because they could see this was a campus with a buzz, with a range of different disciplines, and with a mixture of scientists and business people. It's an environment for open innovation."

At the moment, Esa personnel onsite are using existing buildings, but they will eventually get a purpose-built facility.

The formal opening of Ecsat closes an anomaly whereby the UK, which is now Esa's third largest funder, did not host one of the agency's major research centres.

Britain has recently increased its subscription to the Paris-based organisation by 25%, and Esa has responded by moving its department dedicated to R&D in satellite telecommunications to the UK from the Netherlands.

The re-location also brings with it an Esa director, Magali Vaissiere.

The agency's director general, Jean-Jacques Dordain, said the establishment of Ecsat marked the coming together of a plan to pull the UK back into a more engaged position on space matters.

"There is now a definitive presence of the UK in space, and it is good news that the UK is back to being a strong player," he told BBC News. "It is also good news that Esa is now definitively in the UK."

A significant proportion of Britain's hike in funding for Esa has been directed at telecommunications.

It has committed ?161m (189m euros) over the next three-to-five years to an Esa programme called Artes (Advanced Research in Telecommunications Systems).

This is designed to find the future technologies that will keep the European satellite sector competitive.

For UK companies involved in Artes, past investment has generated a return of more than six to one.

The Astrium company at its Stevenage and Portsmouth bases has benefited most from this investment, and has become one of the world's leading suppliers of spacecraft that relay TV and phone calls around the globe.

The Satellite Applications Catapult joins six other centres set up in the UK by the government's Technology Strategy Board.

All are heavily focused on translating good ideas - many of them originating in academia - into sound business projects.

The UK space sector currently contributes about ?9bn to the national economy, and industry and government have set themselves the target of trying to raise this figure to ?40bn by 2030. SMEs encouraged by the Harwell Catapult will be integral to achieving this goal.

The Catapult will help these fledgling companies find the right expertise and sources of funding to grow their businesses.

"By any measure the UK research sector is world-leading, but it has been a long-standing feeling within the UK that we don't get the economic outputs that some other countries do," said Stuart Martin, the CEO of the new Satellite Applications Catapult.

"We see the structures those countries have got and we can see there is something missing in the UK. The Catapults are there to fill that void."

The European Space Agency's other big centres are:

? The European Space Research and Technology Centre (Estec) in Noordwijk, the Netherlands, is the largest Esa centre. Spacecraft are tested at Estec before being launched.

? The European Space Operations Centre (Esoc) in Darmstadt, Germany, is the location from where Esa spacecraft are controlled during their missions.

? Esrin in Frascati, Italy, is the Esa Centre for Earth Observation.

? The European Space Astronomy Centre (Esac) is Esa's centre dedicated to space science and astronomy, and is based in Villanueva de la Canada, Spain.

? The European Astronaut Centre (Eac) trains Europe's astronauts and is situated in Cologne, Germany.

France does not have a research centre, but it hosts the Esa HQ in Paris.

Jonathan.Amos-INTERNET@bbc.co.uk and follow me on Twitter: @BBCAmos

Source: http://www.bbc.co.uk/news/science-environment-22524233#sa-ns_mchannel=rss&ns_source=PublicRSS20-sa

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Rightist GERB has lead in Bulgaria vote: exit polls

By Iain Rogers MADRID (Reuters) - When Rafa Nadal returned to action in February after seven months out with a knee injury he never thought that just over three months later he would have another five titles in the bag, including two more Masters triumphs. The Spaniard, a former number one and the French Open champion, dropped to five in the world during his enforced absence before storming back to win in Sao Paulo, Acapulco, Indian Wells, Barcelona and now Madrid. ...

Source: http://news.yahoo.com/rightist-gerb-lead-bulgaria-vote-exit-polls-035857462.html

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Woods keeps it dry and wins Players Championship

Tiger Woods posa ante las c?maras con el trofeo despu?s de ganar el torneo Players Championship en TPC Sawgrass, el domingo 12 de mayo de 2013, en Ponte Vedra Beach, Florida. (Foto AP/John Raoux)

Tiger Woods posa ante las c?maras con el trofeo despu?s de ganar el torneo Players Championship en TPC Sawgrass, el domingo 12 de mayo de 2013, en Ponte Vedra Beach, Florida. (Foto AP/John Raoux)

Skier Lindsey Vonn applauds as her boyfriend Tiger Woods receives the trophy after winning The Players Championship golf tournament at TPC Sawgrass, Sunday, May 12, 2013, in Ponte Vedra Beach, Fla. (AP Photo/John Raoux)

Tiger Woods looks toward the crowd as he makes par on the 17th hole during the final round of The Players championship golf tournament at TPC Sawgrass, Sunday, May 12, 2013, in Ponte Vedra Beach, Fla. TIger Woods won The Players Championship. (AP Photo/John Raoux)

Sergio Garcia, of Spain, reacts after hitting his tee shot on the 18th hole into the water during the final round of The Players Championship golf tournament at Sawgrass, Sunday, May 12, 2013, in Ponte Vedra Beach, Fla. (AP Photo/Chris O'Meara)

Tiger Woods gives a thumbs-up as he holds the trophy after winning The Players Championship golf tournament at TPC Sawgrass, Sunday, May 12, 2013, in Ponte Vedra Beach, Fla. (AP Photo/John Raoux)

(AP) ? A weekend filled with sharp words between Tiger Woods and Sergio Garcia came down to one last showdown Sunday in The Players Championship, this one staged across the water in a tiny, terrifying section of the TPC Sawgrass.

Tied for the lead with two holes to play, Woods kept his shots on land and made two pars.

Garcia hit three balls into the water for a quadruple bogey-double bogey finish.

If there was special satisfaction in beating Garcia again, Woods kept that to himself. What mattered was having a chance to win, closing it out like he does so often, and capturing the richest prize on the PGA Tour for the first time in a dozen years.

"We just go out there and play," Woods said. "I had an opportunity to win the golf tournament when I was tied for the lead today, and I thought I handled the situation well and really played well today when I really needed to. And that's something I'm excited about it."

Woods allowed the final hour to turn into a tense duel by hooking his tee shot into the water on the 14th hole for double bogey. But his short game bailed him out to save par on the 15th and make a critical birdie on the 16th, and he was solid on the final two holes for a 2-under 70.

If only it were that simple for the Spaniard.

Garcia was standing on the 17th tee shot, staring across to the island green to watch Woods make his par. He took aim at the flag with his wedge and hung his head when he saw the ball splashed down short of the green. Then, Garcia hit another one in the water on his way to a quadruple-bogey 7. The meltdown was complete when Garcia hit his tee shot into the water on the 18th.

"It's always nice to have a chance at beating the No. 1 player in the world, but unfortunately for me, I wasn't able to this week," Garcia said.

Woods was in the scoring trailer when he watched on TV as Swedish rookie David Lingmerth missed a long birdie putt that would have forced a playoff. It raced by the cup, and Lingmerth three-putted for bogey.

"How about that?" Woods said to his caddie, Joe LaCava as he gave him a hug.

Woods finished on 13-under 275.

He won The Players for the first time since 2001 and became the fifth multiple winner at Sawgrass since The Players moved to this former swamp in 1982. It was his 78th career win on the PGA Tour, four short of the record held by Sam Snead. And it was his first time winning with his girlfriend, Olympic ski champion Lindsey Vonn, at the tournament.

Lingmerth closed with a 72 and finished two shots behind along with Kevin Streelman (67) and Jeff Maggert, who also was tied for the lead until finding the water on the 17th to make double bogey. The 49-year-old Maggert birdied the 18th for a 70.

Garcia took 13 shots to cover the final two holes ? 6-over par ? and tumbled into a tie for eighth.

There was a four-way tie for the lead after Woods made his double bogey, and the infamous 17th green took out Maggert and Garcia. After Garcia went into the water twice, Lingmerth missed an 8-foot birdie putt that would have tied him for the lead.

Given their public sniping at each other over the weekend, it was only fitting that Garcia had the best chance to beat Woods.

Their dispute started Saturday when Garcia complained in a TV interview that his shot from the par-5 second fairway was disrupted by cheers from the crowd around Woods, who was some 50 yards away in the trees and fired them up by taking a fairway metal out of his bag. He said Woods should have been paying attention, and it became a war of the words the next two days.

"Not real surprising that he's complaining about something," Woods said.

"At least I'm true to myself," Garcia retorted. "I know what I'm doing, and he can do whatever he wants."

When they finished the storm-delayed third round Sunday morning, Garcia kept at it, saying that Woods is "not the nicest guy on tour."

Woods had the last laugh. He had the trophy.

Garcia, when asked if he would have changed anything about the flap with Woods, replied, "It sounds like I was the bad guy here. I was the victim. I don't have any regrets of anything."

The real villain was the infamous 17th hole.

"When you've got water in front of the green, that's not a good time to be short of the green. You know, it was close," Maggert said. "What can I say? A wrong shot at the wrong time and you get penalized on this golf course."

It was at the 17th hole five years ago where Garcia won The Players Championship, when Paul Goydos hit into the water in a sudden-death playoff. This time, the island green got its revenge on him. Garcia hit a wedge and felt he caught it just a little bit thin, which is usually all it takes.

"That hole has been good to me for the most part," Garcia said. "Today, it wasn't. That's the way it is. That's the kind of hole it is. You've got to love it for what it is."

Woods earned $1.71 million, pushing his season total to over $5.8 million in just seven tournaments. This is the 12th season he has won at least four times ? that used to be the standard of a great year before he joined the PGA Tour in 1996 ? and this was the quickest he has reached four wins in a year.

It was the second time has won on Mother's Day.

"Sorry, Mom," he said into the camera. "I think she might have had a heart attack. I was in control of the tournament, and I just hit the worst shot I could possibly hit."

Typical of Woods these days, there were questions about where he took the drop ? some 255 yards from the hole. NBC Sports analyst Johnny Miller suggested it was a "borderline" where he took the drop. But Mark Russell, vice president of competition for the PGA Tour, said there was nothing wrong with the drop. Woods conferred with Casey Wittenberg, who said there was "no doubt" that Woods took the drop in the right spot.

"He asked me exactly where it crossed," Wittenberg said. "I told him I thought it crossed on the corner of the bunker, right where he took his drop. And it's all good."

Woods wound up with a double bogey, and he nearly fell out of the lead on the 15th until he saved par with an 8-foot putt.

"The shot that turned the tide was the putt on 15," Woods said. "To go double bogey-bogey would have been huge. But to save a putt there and get some momentum going to the next three holes was big."

Woods and Garcia played four tension-free holes Sunday morning to complete the third round, and they shook hands without words when they finished ? Woods with a 71, Garcia with a 72 to share the 54-hole lead with Lingmerth.

With a three-way tie, Garcia wound up in the final group because he was first to play at the start of the third round.

Garcia, however, continued to fuel the bad feelings between them.

He told Sky Sports, "I'm not going to lie, he's not my favorite guy to play with. He's not the nicest guy on tour." And then he told Golf Channel, "We don't enjoy each other's company. You don't need to be a rocket engineer to figure that out."

Woods downplayed the episode and said it didn't matter who joined him on the tee. "I'm tied for the lead, so I'm right there."

And that's where he usually wins. Woods now is 53-4 in his PGA Tour career when he has at least a share of the lead going into the final round.

Associated Press

Source: http://hosted2.ap.org/APDEFAULT/347875155d53465d95cec892aeb06419/Article_2013-05-12-GLF-Players-Championship/id-0001018b739a4f28ae08e9f04269181d

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To suppress or to explore? Emotional strategy may influence anxiety

May 13, 2013 ? When trouble approaches, what do you do? Run for the hills? Hide? Pretend it isn't there? Or do you focus on the promise of rain in those looming dark clouds?

New research suggests that the way you regulate your emotions, in bad times and in good, can influence whether -- or how much -- you suffer from anxiety.

The study appears in the journal Emotion.

In a series of questionnaires, researchers asked 179 healthy men and women how they managed their emotions and how anxious they felt in various situations. The team analyzed the results to see if different emotional strategies were associated with more or less anxiety.

The study revealed that those who engage in an emotional regulation strategy called reappraisal tended to also have less social anxiety and less anxiety in general than those who avoid expressing their feelings. Reappraisal involves looking at a problem in a new way, said University of Illinois graduate student Nicole Llewellyn, who led the research with psychology professor Florin Dolcos, an affiliate of the Beckman Institute at Illinois.

"When something happens, you think about it in a more positive light, a glass half full instead of half empty," Llewellyn said. "You sort of reframe and reappraise what's happened and think what are the positives about this? What are the ways I can look at this and think of it as a stimulating challenge rather than a problem?"

Study participants who regularly used this approach reported less severe anxiety than those who tended to suppress their emotions.

Anxiety disorders are a major public health problem in the U.S. According to the National Institute of Mental Health, roughly 18 percent of the U.S. adult population is afflicted with general or social anxiety that is so intense that it warrants a diagnosis.

"The World Health Organization predicts that by 2020, anxiety and depression -which tend to co-occur -- will be among the most prevalent causes of disability worldwide, secondary only to cardiovascular disease," Dolcos said. "So it's associated with big costs."

Not all anxiety is bad, however, he said. Low-level anxiety may help you maintain the kind of focus that gets things done. Suppressing or putting a lid on your emotions also can be a good strategy in a short-term situation, such as when your boss yells at you, Dolcos said. Similarly, an always-positive attitude can be dangerous, causing a person to ignore health problems, for example, or to engage in risky behavior.

Previous studies had found that people who were temperamentally inclined to focus on making good things happen were less likely to suffer from anxiety than those who focused on preventing bad things from happening, Llewellyn said. But she could find no earlier research that explained how this difference in focus translated to behaviors that people could change. The new study appears to explain the strategies that contribute to a person having more or less anxiety, she said.

"This is something you can change," she said. "You can't do much to affect the genetic or environmental factors that contribute to anxiety. But you can change your emotion regulation strategies."

Source: http://feeds.sciencedaily.com/~r/sciencedaily/living_well/~3/kBfZE399dDI/130513083314.htm

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